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Description Malarone is a reliable branded medication utilised for both preventing and treating malaria. It's essential to take it daily when travelling to malaria-prone regions. Description Directions Take 1 tablet daily at the same time with food or a milky drink if available. Begin the daily dosage 2 days before entering a malaria risk zone. Continue taking 1 tablet daily throughout your stay and for 7 days after leaving the area. Directions Warnings Like all medicines, this medicine can cause side effects, although not everybody gets them. Look out for the following severe reactions. They have occurred in a small number of people, but their exact frequency is unknown. Severe allergic reactions - signs include: • Rash and itching • Sudden wheezing, tightness of the chest or throat, or difficulty breathing • Swollen eyelids, face, lips, tongue or other part of the body. Contact a doctor immediately if you get any of these symptoms. Stop taking Malarone. • Severe skin reactions • Skin rash, which may blister and look like small targets (central dark spots, surrounded by a paler area with a dark ring around the edge) (erythema multiforme) • Severe widespread rash with blisters and peeling skin, particularly occurring around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome). If you notice any of these symptoms contact a doctor urgently. Most of the other side effects reported have been mild and have not lasted very long. Very common side effects These may affect more than 1 in 10 people: • Headache • Feeling sick and being sick (nausea and vomiting) • Stomach pain • Diarrhoea. Common side effects These may affect up to 1 in 10 people: • Dizziness • Sleeping problems (insomnia) • Strange dreams • Depression • Loss of appetite • Fever • Rash, which may be itchy • Cough. Common side effects which may show up in your blood tests are: • Reduced numbers of red blood cells (anaemia), which can cause tiredness, headaches and shortness of breath • Reduced numbers of white blood cells (neutropenia), which may make you more likely to catch infections • Low levels of sodium in the blood (hyponatraemia) • An increase in liver enzymes. Uncommon side effects These may affect up to 1 in 100 people: • Anxiety • An unusual awareness of the abnormal beating of the heart (palpitations) • Swelling and redness of the mouth • Hair loss • Itchy, bumpy rash (hives). Uncommon side effects that may show up in your blood tests: • An increase in amylase (an enzyme produced in the pancreas). Rare side effects These may affect up to 1 in 1,000 people: • Seeing or hearing things that are not there (hallucinations). Other side effects Other side effects have occurred in a small number of people, but their exact frequency is unknown. • Inflammation of the liver (hepatitis) • Blockage of the bile ducts (cholestatis) • Increase in heart rate (tachycardia) • Inflammation of the blood vessels (vasculitis), which may be visible as red or purple raised spots on the skin but can affect other parts of the body • Fits (seizures) • Panic attacks, crying • Nightmares • Severe mental health problem in which the person loses contact with reality and is unable to think and judge clearly • Indigestion • Mouth ulcers • Blisters • Peeling skin • Increased sensitivity of the skin to sunlight. Other side effects that may show up in your blood tests: • A decrease in all types of blood cells (pancytopenia). Reporting of side effects If you get any side effects talk to your doctor or pharmacist. This includes any possible side effects not listed. By reporting side effects, you can help provide more information on the safety of this medicine. Warnings Ingredients The active ingredients are 250 mg of atovaquone and 100 mg of proguanil hydrochloride in each tablet. The other ingredients are: Tablet core: poloxamer 188, microcrystalline cellulose, hydroxypropyl cellulose, povidone K30, sodium starch glycollate (Type A), magnesium stearate. Tablet coating: hypromellose, titanium dioxide (E171), iron oxide red (E172), macrogol 400 and polyethylene glycol 8000. Ingredients FAQs How does Malarone work? Malarone contains atovaquone and proguanil hydrochloride, which kill the malaria parasite transmitted by infected mosquitoes. What are the side effects of Malarone? Side effects are typically mild, including stomach pain, dizziness, headaches, nausea, diarrhoea, coughing, low mood, and skin reactions. Vivid dreams may also occur. For full details, consult the patient information leaflet. How effective is Malarone? Protection begins 1-2 days after starting the course, so it's crucial to start before your trip. Consistent use is necessary for maximum effectiveness. Malarone provides 95% protection when combined with mosquito bite prevention measures. Who can use Malarone? Individuals over 18 who are clinically suitable can be prescribed Malarone. However, ensure it's suitable for your destination, as not all malaria prevention drugs are effective everywhere. Is