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Description Differin Cream treats moderate to severe acne, offering relief and preventing future flare-ups. Visible improvements typically occur within 2-3 weeks of use. Description Directions Wash hands thoroughly with soap and water before use. Remove the cap from the tube of gel. Attach one disposable applicator to the tube by screwing it on. Gently squeeze the tube to fill the applicator with gel until the plunger stops moving. Remove the applicator from the tube and replace the cap. Lie on your back with your knees bent and apart. Insert the applicator tip deep into the vagina and slowly push the plunger to release the gel. Carefully remove the applicator and dispose of it immediately. Repeat this process nightly for 5 nights, using a fresh applicator each time. Do not use more gel than prescribed, as it can increase the risk of side effects. Consult your doctor or pharmacist for guidance if needed. If you miss a dose, do not double up. Simply apply the gel at the next scheduled bedtime. Complete the full course of metronidazole gel as directed, even if symptoms improve, to ensure complete resolution of the infection. Directions Warnings Like all medicines, this medicine can cause side effects, although not everybody gets them. Contact a doctor right away if you notice any of the following symptoms - you may need urgent medical treatment: Swelling of the face, lips or throat, which makes it difficult to swallow or breathe; rash, itching, hives and dizziness. This could be a sign of angioedema or a severe allergic reaction (frequency not known or cannot be estimated from the available data). Common side effects (may affect up to 1 in 10 people): • Dry skin • Irritation of the skin • Burning sensation of the skin • Redness of the skin (erythema). Uncommon (may affect up to 1 in 100 people): • Local skin reaction (contact dermatitis) • Skin discomfort • Sunburn • Itching of the skin (pruritus) • Peeling skin (exfoliation) • Flare-up of acne. Not known (frequency cannot be estimated from the available data): • Allergic contact reaction • Pain or swelling of the skin • Irritation, redness, itching or swelling of the eyelids • Darkening of fair skin • Lightening of darker skin • Application site burn. Application site burns (mostly superficial burns but also second-degree or severe burns) have been reported. Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed. By reporting side effects, you can help provide more information on the safety of this medicine. Warnings Ingredients The active substance is adapalene. Differin contains 0.1% w/w of adapalene. The other ingredients are carbomer 934P, macrogol-20 methyl glucose sesquistearate, glycerol (E422), natural squalane, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), disodium edetate, methyl glucose sesquistearate, phenoxyethanol, cyclomethicone, sodium hydroxide and purified water. Ingredients FAQs What is Differin Cream? Differin Cream is a topical treatment for acne containing adapalene, a retinoid. It reduces inflammation, reduces the production of skin cells and increases the turnover of surface skin cells and regulates oil production, effectively treating spots, pimples, and blackheads on the chest, face, or back. How does Differin Cream work? Differin Cream: • Slows skin cell turnover to clear breakouts and prevent acne recurrence • Reduces inflammation and redness • Regulates skin oil production to prevent further outbreaks. How long does Differin Cream last? The duration varies based on cream size and affected skin area. Using only the prescribed amount is crucial. Applying more or more frequently won't expedite acne resolution. How long does Differin Cream take to work? Improvement typically starts within 2 to 3 weeks of Differin Cream use, but several months may be needed for significant acne improvement. A doctor will assess effectiveness after 3 months. How effective is Differin Cream? Differin Cream is highly effective, with clinical studies showing up to an 87% decrease in acne after 12 weeks of use. What if I apply too much or miss a dose? Applying excess Differin Cream won't enhance results and may irritate the skin. Rinse off excess and resume treatment the next day if skin is red or irritated. If a dose is missed, resume treatment when remembered.FAQs