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What is Phenergan Elixir The active ingredient in Phenergan is promethazine hydrochloride, which is an antihistamine that belongs to a group of medicines known as phenothiazines. When you have an allergic reaction, your body creates a natural substance called histamine. Histamine sends signals around your body that trigger symptoms of allergy, such as a runny nose or watery eyes. Antihistamines work by blocking histamine, which prevents your symptoms so you wont have to tolerate an allergic reaction. Who can use Phenergan Elixir Suitable for Adults and children over the age of 2